In this short course, we will present an overview of the PlutoSDR radio by Analog Devices, including its I/O characteristics, as well as its onboard ARM processor and FPGA. Several demonstrations will be provided, including ARM targeting of an FM radio transmitter. Furthermore, Mathworks tools (MATLAB, Simulink) for designing radio systems using the PlutoSDR will be presented, including system objects. ARM and HDL targeting will also be discussed, as well as future plans for using Codegen planned for future. Demonstrations using Mathworks tools and the PlutoSDR include WLAN image transmission and transmit repeat.